The organisation has a number of core projects including providing specialist equipment and wheelchairs for disabled children and innovative and pioneering therapy programmes.  Caudwell children's UK Autism Initiative helps to unlock the lives of children with autism.

There is also a "Destination Dreams" programme which provides organised holidays of a lifetime for terminally ill children and their families.

The Caudwell Children's "Enable Sport" programme provides specially adapted sports equipment for gifted and talented young disabled athletes